Table 3.
The Different Side Effects Reported in All 3 Doses and Their Correlation with the Type of Vaccine After the First and Second Dose
| Side Effects | First Dose | P value | Second Dose | P value | Third Dose | |||
|---|---|---|---|---|---|---|---|---|
| Pfizer | Oxford | Pfizer | Oxford | Pfizer | Oxford | |||
| N=772 | N=217 | N=816 | N=162 | N=142 | N=2 | |||
| Local side effects, n (%) | ||||||||
| Swelling at injection site | 216 (27.9) | 72 (33.1) | 0.136 | 185 (22.6) | 36 (22.2) | 0.901 | 34 (23.9) | 1 (50) |
| Redness at injection site | 132 (17) | 51 (23.5) | 0.032 | 125 (15.3) | 24 (14.8) | 0.871 | 23 (16.1) | 1 (50) |
| Pain at injection site | 518 (67) | 140 (64.5) | 0.476 | 432 (52.9) | 64 (39.5) | 0.002 | 66 (46.4) | 1 (50) |
| Systemic side effects | ||||||||
| Fatigue | 420 (54.4) | 159 (73.2) | 0.000 | 417 (51.1) | 88 (54.3) | 0.454 | 60 (42.2) | 2 (100) |
| Fever | 194 (25.1) | 125 (57.6) | 0.000 | 208 (25.4) | 62 (38.2) | 0.001 | 37 (26) | 2 (100) |
| Headache | 257 (33.2) | 97 (44.7) | 0.002 | 258 (31.6) | 61 (37.6) | 0.134 | 38 (26.7) | 2 (100) |
| Joint pain | 168 (21.7) | 70 (32.2) | 0.001 | 164 (20) | 38 (23.4) | 0.335 | 25 (17.6) | 1 (50) |
| Muscle pain | 214 (27.7) | 86 (39.6) | 0.001 | 176 (21.5) | 44 (27.1) | 0.119 | 30 (21.1) | 1 (50) |
| Nausea | 92 (11.9) | 36 (16.5) | 0.07 | 76 (9.3) | 12 (7.4) | 0.439 | 7 (4.9) | 0 |
| Vomiting | 23 (2.9) | 10 (4.6) | 0.238 | 20 (2.4) | 1 (0.6) | 0.040* | 3 (2.1) | 0 |
| Diarrhea | 31 (4) | 12 (5.5) | 0.334 | 36 (4.4) | 5 (3) | 0.442 | 5 (3.5) | 0 |
| Bruises | 29 (3.7) | 9 (4.1) | 0.791 | 23 (2.8) | 6 (3.7) | 0.556* | 2 (1.4) | 0 |
| Bleeding | 17 (2.2) | 5 (2.3) | 0.929* | 18 (2.2) | 4 (2.4) | 0.838* | 0 | 0 |
| Chills | 108 (13.9) | 67 (30.8) | 0.000 | 110 (13.4) | 28 (17.2) | 0.204 | 13 (9.1) | 1 (50) |
| Sore throat | 53 (6.8) | 22 (10.1) | 0.108 | 39 (4.7) | 10 (6.1) | 0.458 | 2 (1.4) | 0 |
| Allergic reaction | 26 (3.3) | 12 (5.5) | 0.143 | 34 (4.1) | 7 (4.3) | 0.929 | 0 | 0 |
| Runny nose | 35 (4.5) | 15 (6.9) | 0.158 | 33 (4) | 7 (4.3) | 0.871 | 1 (0.7) | 0 |
| Cough | 33 (4.2) | 14 (6.4) | 0.183 | 31 (3.7) | 9 (5.5) | 0.302 | 0 | 0 |
| Shortness of breath | 57 (7.3) | 15 (6.9) | 0.813 | 57 (6.9) | 13 (8) | 0.639 | 2 (1.4) | 0 |
| Chest pain | 57 (7.3) | 15 (6.9) | 0.813 | 59 (7.2) | 13 (8) | 0.724 | 1 (0.7) | 0 |
| Fast or irregular heartbeat | 72 (9.3) | 23 (10.5) | 0.574 | 63 (7.7) | 22 (13.5) | 0.016 | 1 (0.7) | 0 |
Notes: *For this test, the number of expected count was lower than 5 for Pearson’s chi square test. Therefore, likelihood ratio was considered. The numbers in bold indicate the P values for which the side effects are significantly correlated to the type of vaccine.