Table 2.

Patients with hospitalization and amputation across cohorts

	Unmatched Cohorts						Propensity Score–Matched Cohorts
	Comparison #1 (C1)			Comparison #2 (C2)			Comparison #1 (C1)
	TWO2 N = 91	NO TWO2 N = 111	p	TWO2 ONLY N = 58	OTHER TX ONLY N = 34	p	TWO2 N = 70	NO TWO2 N = 70	p
Patients with hospitalization, n (%)	6 (6.6)	60 (54.1)	<0.0001	4 (6.9)	20 (58.8)	<0.0001	5 (7.1)	28 (40.0)	<0.0001
Patients with amputation, n (%)	11 (12.1)	46 (41.4)	<0.0001	8 (13.8)	12 (35.3)	0.016	6 (8.6)	22 (31.4)	0.0007

Comparison #1 (C1) compares patients who ever received TWO2 (TWO2) to those who never received TWO2 (NO TWO2). Patients in both cohorts may have also received other adjunctive therapy. Comparison #2 (C2) compares patients who only received TWO2 and no other adjunctive therapy (TWO2 ONLY) to those who received NPWT, SS, and/or GF, but not TWO2 (OTHER TX ONLY). Propensity score matching was performed on the following 9 factors; age, sex, ethnicity, wound severity, prior amputation, use of offloading, use of NPWT, use of SS, use of GF. All patients received appropriate SOC.