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A) Structures of PHICS6 and PKC binder VS1012. B), C) PHICS6-induced phosphorylation of endogenous BCR-ABL (B) and ABL (C) in K562 cells by endogenous PKC detected with phospho-ABL (Thr735) antibody. Cells were incubated with 10 μM of compound for 4 h in each treatment. D) Effect of PHICS6 on viability of K562 and KCl22-s cells.
