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. 2022 Sep 19;2022:2694377. doi: 10.1155/2022/2694377

Table 2.

Univariate and multivariable analyses of prognostic factors for 5-year survival in patients with glioma.

Univariate analysis Multivariate analysis
HR P > |z| 95% CI HR P > |z| 95% CI
KLHDC8A expression 3.787 <0.001 2.684 5.344 3.028 <0.001 2.001 4.581
KLHDC8A+CD68+ expression 2.271 0.001 1.430 3.606 1.822 0.022 1.090 3.044
Sex
 Male vs. female 1.461 0.024 1.052 2.030 1.701 0.004 1.188 2.433
Age (y)
 ≤60 vs. >60 2.098 <0.001 1.514 2.907 1.687 0.007 1.151 2.472
Histological classification
 a (AA, AG, AOA, AGG, and PA) vs. b (A) vs. c (GBM) vs. d (MG) vs. e (DA and PPXA) 1.271 0.001 1.097 1.472 1.027 0.788 0.846 1.247
IDH1
 IDH1+ vs. IDH1- 0.660 0.011 0.479 0.910 0.653 0.018 0.459 0.928
S100A4 1.286 0.125 0.932 1.775
CD25 1.410 0.046 1.006 1.976 0.386 0.846 0.579 1.235
Cd66b 1.289 0.133 0.925 1.795
CD68+CD163+ 2.170 <0.001 1.560 3.019 1.093 0.723 0.669 1.785
S100A4+CD163+ 1.728 0.001 1.247 2.393 0.774 0.267 0.493 1.216
Grade
 I vs. II vs. III vs. IV 2.284 <0.001 1.803 2.893 1.716 <0.001 1.284 2.294

P < 0.05. a: anaplastic astrocytoma, anaplastic glioma and anaplastic ganglioglioma. b: anaplastic oligoastrocytoma, astrocytoma, diffuse astrocytoma, and oligodendroglioma. c: glioblastoma. d: mixed glioma.