TABLE 2.
Summary of active/completed phase I and II clinical trials using MSCs to treat patients with BPD
| Study | NCT number | Cell type | Route | Number of patients (n) | Dosage (million cells/kg) |
|---|---|---|---|---|---|
| MSC drug on‐going clinical trials | |||||
| Medipost Co Ltd. 51 , 52 | NCT02023788 | PNEUMOSTEM | Intratracheal | 8 | 10–20 |
| NCT04003857 | Intratracheal | 60 | 10 | ||
| United Therapeutics 49 | NCT03857841 | UNEX‐42 | Not specified | 18 | 20–200 pmol phospholipid/kg |
| Meridigen Biotech Co., Ltd. 50 | NCT03631420 | UMC119‐01 | Not specified | 9 | 3–30 |
| Phase II | |||||
| Medipost America Inc. 53 | NCT02381366 | hUCB‐MSCs | Intratracheal | 12 | 10–20 |
| Children's Hospital of Fudan University 52 | NCT03645525 | hUC‐MSCs | Intratracheal | 180 | 20 |
| Children's Hospital of Chongqing Medical University 54 | NCT03774537 | hUC‐MSCs | Intravenous | 20 | 1–5 |
| Children's Hospital of Chongqing Medical University 55 | NCT03601416 | hUC‐MSCs | Intravenous | 72 | 2.5–5 |
| Medipost Co. Ltd 56 | NCT03392467 | hUC‐MSCs | Intraperitoneal | 60 | Not specified |
| Phase I | |||||
| Medipost Co. Ltd 47 | NCT01297205 | hUCB‐MSCs | Intratracheal | 9 | 10–20 |
| Samsung Medical Center 57 | NCT01632475 | hUCB‐MSCs | Intratracheal | 9 | 10–20 |
| Children's Hospital of Chongqing Medical University 58 | NCT03558334 | hUC‐MSCs | Intravenous | 12 | 1–5 |
| Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Caja 59 | NCT02443961 | hUC‐MSCs | Not specified | 10 | 5 |
| Daping Hospital and the Research Institute of Surgery of the Third Military Medical University 60 | NCT03378063 | hUCB‐MSCs | Not specified | 100 | Not Specified |
| Children's Hospital of Chongqing Medical University 61 | NCT03873506 | hUC‐MSCs | Intravenous | 30 | 1–5 |
| Guangdong Women and Children Hospital 62 | NCT03683953 | MSCs | Intratracheal | 200 | 25 |
| China Medical University Hospital 63 | NCT01207869 | UC‐MSCs | Intratracheal | 10 | 3 |
| Ottawa Hospital Research Institute 64 | NCT04255147 | Allogeneic UC‐MSCs | Intravenous | 9 | 1–10 |
| Vinmec Research Institute of Stem Cell and Gene Technology 65 | NCT04062136 | hUC‐MSCs | Endotracheal and Intravenous | 10 | 1 |
| Liem et al. 66 | ‐ | Autologous BM‐MNCs | Intravenous | 1 | 1 |
| Lim et al. 67 | ‐ | Allogeneic hAECs | Intravenous | 6 | 1 |
| Baker et al. 68 | ‐ | hAECs | Intravenous | 24 | 2–30 |
| Nguyen et al. 14 | ‐ | Allogeneic UC‐MSCs | Intravenous | 4 | 1 |