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. 2022 Oct 2;13:5789. doi: 10.1038/s41467-022-33461-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Overview of experiment and analysis to identify changes in protein expression associated with bortezomib treatment of AL cells. Created with BioRender.com. b Quantification of indicated BCL-2 family proteins. c Changes in BCL-2 family protein expression during bortezomib treatment. d Unbiased clustering analysis of proteins modulated by bortezomib treatment of ALMC-1 and ALMC-2 cell lines. Clustering was performed using the complete-linkage method based on Euclidean distance, and sub-clusters were separated by k means partitioning. e Principal component analysis of bortezomib-treated cells. f Ranking of all ~7900 quantified proteins with BCL-2 family proteins indicated in red. g Gene ontology (GO) biological processes (BP) that are associated with increased protein levels in ALMC-1 versus ALMC-2 cells. h–i Gene set enrichment analysis (GSEA) in ALMC-1 cells relative to ALMC-2 for proteins associated with h oxidative phosphorylation or i mitochondrial electron transport. j GO BP associated with increased protein levels in ALMC-2. k, l GO BP associated with k increasing or l decreasing protein levels during bortezomib treatment. m, n GO BP associated with increasing protein levels during bortezomib treatment specifically in ALMC-1 (m) or ALMC-2 (n) cells. P-values were calculated using linear regression and adjusted using Bonferroni correction for f, g, and j–n.