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. 2022 Oct 2;7:345. doi: 10.1038/s41392-022-01197-3

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© The Author(s) 2022, corrected publication 2022

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Fig. 3 — Regulation network of hPGC specification. BMP- and WNT signaling promote the hPGCLC specification via regulating TFAP2C and SOX17. SOX17 is a critical regulator for hPGC specification and works upstream of BLIMP1. TFAP2C activates SOX17 expression. Final effects of hPGC specification promote germline development and pluripotency, while suppress somatic programs. The figure was drawn by Figdraw. Arrows and blunt-ended arrows depict positive and negative regulation, respectively. Dashed lines indicate synergetic role