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. 2022 Sep 19;10:952670. doi: 10.3389/fbioe.2022.952670

FIGURE 3.

FIGURE 3

3D comb-shaped polycation (HA-SS-PGEA) nanofiber aerogel as miR-26a carrier for bone defect healing (Li et al., 2020). (A) Schematic diagram of the combination of HA-SS-PGEA and miR-26a nanoparticles (NPs) and the 3D nanofiber aerogel for bone defect repair. (B) CLSM images of live/dead staining mediated by various miRNA-containing NPs, including PEI, poly (glycidyl methacrylate) modified with target components, biodegradable groups, and short ethanolamine (PGEA), HA-SS-PGEA. (C) After 4 weeks of implantation, H&E staining (A) and Masson’s trichrome staining (MTC) (B) of rat cranial tissue were performed. (D) Representative planar X-ray films after 4 weeks of implantation. (E) SEM images of 3D mixed nanofiber aerogels. (blank, without 3D aerogel or NPs; miR-NC, negative control; CLSM, confocal laser scanning microscope; SEM, scanning electron microscope) Copyright 2020 Wiley-VCH GmbH. Reproduced with permission from John Wiley and Sons.