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. 2022 Sep 19;10:952670. doi: 10.3389/fbioe.2022.952670

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Copyright © 2022 Wang, Cui, Liu, Li, Sun, Xu, Peng, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Monodispersed Bioactive Glass Nanoclusters (BGNCs) as vectors of miRNA promote osteogenic regeneration (Xue et al., 2017). (A) Schematic diagram of BGNC manufacturing and miRNA delivery applications. (a) Branched PEI-assisted synthesis of BGNCs. (b) miRNA loading. (c) miRNA delivery regulates the osteogenic activity of stem cells in vitro and bone regeneration in vivo. (B) Bone tissue samples were taken for H&E staining and MTC staining after 4 weeks of implantation in the rat parietal bones’ defect, with the black line representing 1 mm and the white line representing 100 µm. (NC, using the pure fibrin glue hydrogel as negative control; BGN, bioactive glass nanoparticle; BGN@miRNA, BGN with miRNA; BGNC@miRNA, BGNC with miRNA; TEOS, tetraethyl orthosilicate.) Copyright 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Reproduced with permission from John Wiley and Sons.