TABLE 1.
Summary of target genes of different signaling pathways by miRNAs.
| Signaling pathways | Target gene | miRNA | Cell type | Effect on osteogenesis |
|---|---|---|---|---|
| BMP/SMAD | SMAD2 | miR-10b | HADSCs | Promotion |
| BMP-7 | miR-542-3p | Calvarial osteoblasts | Inhibition | |
| BMP2 | miR-6979-5p/214 | MC3T3-E1 | Inhibition | |
| BMPR | miR-125b | HBMSCs | Inhibition | |
| RUNX2 | miR-203 | HBMSCs | Inhibition | |
| SMAD7 | miR-877-3p/15b/590-5p | HBMSCs | Promotion | |
| SMAD4 | miR-664-3p | MC3T3-E1 | Inhibition | |
| SMAD5 | miR-135/25-3p | hUC-MSCs | Inhibition | |
| Dlx5 | miR-141/200a | MC3T3-E1 | Inhibition | |
| Noggin | miR-200c | HBMSCs | Promotion | |
| Wnt/β-catenin | Wnt2b | miR-370-5p | HBMSCs | Inhibition |
| Wnt7a | miR-889 | BMMSCs | Inhibition | |
| Wnt3a | miR-503 | MC3T3-E1 | Inhibition | |
| Wnt1 | miR-22-3p/miR-34a-5p | — | Inhibition | |
| Wnt10b | miR-33b-5p | hUC-MSCs | Inhibition | |
| Wnt11 | miR-154-5p | ADSC | Inhibition | |
| DKK-3 | miR-129-5p | BMSCs | Promotion | |
| APC | miR-27a/675 | HBMSCs | Inhibition | |
| GSK-3β | miR-26a | BMSCs | Promotion | |
| DKK1/Kremen2 | miR-291a-3p | BMSCs | Promotion | |
| PPARγ | miR-381/130a/27a | BMSCs | Promotion | |
| LRP6 | miR-30e | Preadipocyte 3T3-L1 | Inhibition | |
| LRP5 | miR-23a | BMSCs | Inhibition | |
| PTEN/PI3K/AKT | PTEN | miR-19b/214/21 | MC3T3-E1 | Promotion |
| MAPK | FGF2 | miR-16 | BMSC | Inhibition |