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. 2022 Sep 19;13:991879. doi: 10.3389/fphar.2022.991879

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Copyright © 2022 Shen, Wang, Xu, Chen, Zhu, Cheng, Fang, Liu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic differences between responders and non-responders to anti-VEGF treatment combining nAMD and PCV. (A) Principal component analysis (PCA) model showed significant difference. (B) Partial least squares discriminant analysis (PLS-DA) model showed significant difference. (C) The permutation test demonstrated that PLS-DA model did not overfit. (D) Volcano plot of the differential metabolites between responders and non-responders. Blue and red dots indicated down-regulated and up-regulated metabolites, respectively. (E) Venn plot of the differential metabolites between responders and non-responders in AMD (30 metabolites) and the differential metabolites between responders and non-responders in PCV (47 metabolites).