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. 2022 Sep 19;13:989985. doi: 10.3389/fgene.2022.989985

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Copyright © 2022 Wang, Zhao, Wang, Zhao, Liang, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The volcano plot shows fold changes for genes differentially expressed between TCGA-clusters A and C. The differentially expressed PCGI methylation-driven genes are highlighted in the figure. (B) Boxplots of differentially expressed PCGI methylation-driven genes between clusters A and C. (C) The volcano plot shows fold changes for genes differentially expressed between CGGA-clusters A and C. The differentially expressed PCGI methylation-driven genes are highlighted in the figure. (D) Heatmap and hierarchical clustering of normalized immune cell infiltration score of TCGA samples. (E) Violin plots for the distributions of StromalScore, immuneScore, ESTIMATEScore, and TumorRurity of TCGA samples. (F) Heatmap and hierarchical clustering of normalized immune cell infiltration score of CGGA samples. (G) Violin plots for the distributions of StromalScore, immuneScore, ESTIMATEScore, and TumorRurity of CGGA samples.