Table 10.

RANO-BM Criteria for Response Assessment

Parameter	Complete Response	Partial Response	Stable Disease	Progressive Disease
Target lesions	No evidence of disease	≥30% decrease in sum of longest diameter of target lesions	Response between <30% decrease to <20% increase in sum of longest diameter of target lesions	≥20% in sum of longest diameter of target lesions
Nontarget lesions	No evidence of disease	Stable/improved	Stable/improved	Unequivocal radiographic progression
Steroids	None	Stable/reduced	Stable/reduced	Not applicable
Clinical status	Stable/improved	Stable/improved	Stable/improved	Deterioration

Abbreviations: RANO-BM, Response Assessment in Neuro-Oncology - Brain Metastases.