Table 2.

Trabecular parameters of wild‐type (Lgals3 ^+/+), heterozygous (Lgals3‐R200S^KI/+), and mutant (Lgals3‐R200S^KI/KI) mice ^a . BV/TV, bone volume/total volume; Conn.D, connectivity density; Tb.N, trabecular number; Tb.Sp, trabecular spacing; Tb.Th, trabecular thickness.

Variables compared	Females		Males
	Femur	L3	Femur	L3
BMD (g·cm−3)
Wild‐type	0.075 ± 0.010	0.133 ± 0.013	0.181 ± 0.009	0.213 ± 0.010
Heterozygote	0.065 ± 0.005	0.131 ± 0.007	0.206 ± 0.018	0.224 ± 0.017
Mutant	0.096 ± 0.012	0.186 ± 0.015*	0.210 ± 0.016	0.219 ± 0.015
BV/TV (%)
Wild‐type	3.95 ± 0.58	b	14.67 ± 0.82	19.37 ± 0.78
Heterozygote	3.07 ± 0.29	b	16.59 ± 1.86	20.07 ± 1.62
Mutant	5.48 ± 0.91	b	16.69 ± 1.29	16.08 ± 1.32
Tb.Th (mm)
Wild‐type	0.055 ± 0.002	b	0.061 ± 0.002	0.055 ± 0.001
Heterozygote	0.055 ± 0.002	b	0.062 ± 0.001	0.056 ± 0.001
Mutant	0.057 ± 0.002	b	0.061 ± 0.002	0.053 ± 0.001
Tb.Sp (mm)
Wild‐type	0.408 ± 0.035	b	0.246 ± 0.007	0.210 ± 0.005
Heterozygote	0.435 ± 0.019	b	0.242 ± 0.014	0.214 ± 0.009
Mutant	0.383 ± 0.019	b	0.233 ± 0.010	0.209 ± 0.008
Tb.N (mm−1)
Wild‐type	0.735 ± 0.110	b	2.407 ± 0.116	3.508 ± 0.100
Heterozygote	0.558 ± 0.045	b	2.627 ± 0.258	3.515 ± 0.236
Mutant	0.923 ± 0.131	b	2.693 ± 0.177	3.677 ± 0.169
Conn.D (mm−3)
Wild‐type	33.36 ± 5.73	64.55 ± 8.39	97.74 ± 7.08	120.25 ± 4.90
Heterozygote	22.99 ± 2.64	54.12 ± 3.15	110.63 ± 13.55	124.36 ± 12.38
Mutant	41.23 ± 7.82	87.38 ± 9.45	126.94 ± 13.06*	139.49 ± 9.24
Bone length (mm)
Wild‐type	13.33 ± 0.16	3.60 ± 0.05	13.06 ± 0.06	3.67 ± 0.04
Heterozygote	13.22 ± 0.08	3.66 ± 0.04	13.22 ± 0.11	3.76 ± 0.05
Mutant	13.23 ± 0.09	3.67 ± 0.04	13.06 ± 0.11	3.74 ± 0.04

^a Values are expressed as mean ± SEM (n = 9–15); Holm‐Sidak post hoc analysis adjusted P‐values compared with wild‐type; bold values highlight *P < 0.05.

^b Data are displayed in Fig. 2.