Fig. 9.

Schematic depicting how MGB1 regulates the progression of resistant cells through cyclin and NF‐κB regulation. The surviving cells after long‐term treatment with trastuzumab showed resistance. MGB1 is upregulated in resistant cells and regulates progression (cell proliferation, migration, and invasion ability; proliferation is critical for cell viability) through the induction of NF‐κB‐dependent cyclin D1 expression and cyclin E1 expression. Cyclin D1 and E1 expression affected cyclin A2 expression.