Fig. 6.

Prospective signaling pathways of upregulated STAG1 positive co‐expression genes in hepatocellular carcinoma. We performed weighted gene co‐expression network analysis (WGCNA) to determine the high‐CAGS HCC phenotype‐related module genes. (A) A soft threshold of 19 was set to construct a scale‐free topological model. (B–C). A blue gene module exhibited a highly positive correlation with the CAGS‐high phenotype in HCC. (D) The blue gene module was predominantly enriched in the mitotic cell cycle process. (E) The similarity scores of the STAG1 putative transcriptional targets were calculated, and PDS5A and ID1 were identified as the core genes in blood vessel development and mitotic cell cycle process, respectively. CAGS, cohesin‐associated genes scores; HCC, hepatocellular carcinoma.