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Growth and drug sensitivity test of K. lactis cells showing the synergistic hyperresistant phenotype created by a combination of KlPDR5 overexpression and sit4 mutation. K. lactis cells were grown in liquid minimal medium to stationary phase and tested on GlyYP and GYP supplemented with oligomycin (Oli) and econazole (Eco). The plates were incubated at 30°C for 4 days before being photographed. WT, wild type.
