Table 1.
Demographic and clinical characteristics of patients treated with vancomycin for inflammatory conditions of the pouch.
| No Improvement on Vancomycin at 4 weeks | Improvement on Vancomycin at 4 weeks | P | |||
|---|---|---|---|---|---|
| n = 20 | n = 21 | ||||
| n | % | n | % | ||
| Age at initiation of vancomycin (Median, IQR) | 49 | 35–59 | 44.5 | 30–53.5 | 0.456 |
| Female Sex | 8 | 40 | 14 | 67 | 0.087 |
| Race | 0.152 | ||||
| White | 19 | 95 | 16 | 76 | |
| Non-White | 1 | 5 | 5 | 24 | |
| Smoking status | 0.764 | ||||
| Never | 16 | 80 | 17 | 81 | |
| Current | 1 | 5 | 2 | 10 | |
| Former | 3 | 15 | 2 | 10 | |
| Family history of IBD | 1 | 5 | 3 | 14 | 0.317 |
| Indication for surgery | 0.614 | ||||
| Medically-refractory colitis | 17 | 85 | 17 | 81 | |
| Dysplasia or cancer | 0 | 0 | 1 | 5 | |
| Other indication | 3 | 5 | 3 | 10 | |
| Disease extent prior to surgerya | 0.982 | ||||
| Proctitis | 1 | 6 | 1 | 6 | |
| Left-sided colitis | 3 | 19 | 3 | 17 | |
| Extensive colitis | 12 | 75 | 14 | 78 | |
| Stage of IPAA Surgerya | 0.706 | ||||
| I | 3 | 18 | 4 | 24 | |
| II | 9 | 53 | 10 | 59 | |
| III | 5 | 29 | 3 | 18 | |
| Inflammatory Condition of the Pouch | 0.143 | ||||
| Chronic Antibiotic Dependent Pouchitis | 7 | 35 | 20 | 48 | |
| Chronic Antibiotic Refractory Pouchitis | 6 | 30 | 9 | 43 | |
| Crohn’s-like Disease of the Pouch | 7 | 35 | 2 | 10 | |
| Primary Sclerosing Cholangitis | 2 | 10 | 1 | 5 | 0.548 |
| No. antibiotics prior to vancomycin | 0.351 | ||||
| 1 or 2 | 2 | 10 | 3 | 14 | |
| 3 | 3 | 15 | 5 | 24 | |
| 4 | 8 | 40 | 4 | 19 | |
| 5 or more | 7 | 35 | 9 | 43 | |
| Biologic use after IPAA | 12 | 60 | 13 | 62 | 0.901 |
| Clostridioides difficile infection after IPAA | 4 | 20 | 4 | 19 | 1.000 |
Disease extent and number of stages in IPAA surgery were unknown for 7 patients.