Table 3.
Association between brain structure, cognitive function and IBD. (Linear regression)
| Variable | Participants | IBD patients | Beta (95%CI) a | p |
|---|---|---|---|---|
| Brain structure | ||||
| Total volume of white matter hyperintensities | 19847 | 194 | −311.80 (−1103.85 to 480.24) | 0.440 |
| Volume of white matter | 21039 | 205 | −239.99 (−5622.71 to 5142.73) | 0.930 |
| Volume of gray matter | 21039 | 205 | −1042.44 (−5992.91 to 3908.04) | 0.680 |
| Volume of brain | 21039 | 205 | −1282.46 (−9567.11 to 7002.20) | 0.762 |
| Volume of hippocampus (total) | 21022 | 205 | −61.10 (−171.85 to 49.64) | 0.280 |
| Volume of gray matter in hippocampus (total) | 21034 | 205 | −78.81 (−179.39 to 21.78) | 0.125 |
| Cognitive function | ||||
| Reaction time change | 44908 | 408 | 12.32 (1.97, 22.67) | 0.020 |
| Visual memory change | 45316 | 410 | 0.16 (−0.23 to 0.56) | 0.414 |
| Verbal-numerical reasoning change | 15098 | 136 | −0.09 (−0.38 to 0.20) | 0.545 |
| Prospective memory change | 15467 | 139 | 0.04 (−0.05 to 0.12) | 0.397 |
Adjusted for age, age-square, sex, race, education, Townsend deprivation index, body mass index, alcohol drinker status, smoking status, physical activity, family history of dementia.