TABLE 5.
Single-Nucleotide Polymorphism Association With the Time to Prostate-Specific Antigen Progression, Ranked by Unadjusted P Values
| MAFa |
||||||
|---|---|---|---|---|---|---|
| SNP | Gene | P TOT | P GT | HRGT (95% CI) | White Men | Black Men |
|
| ||||||
| rs80275835 | SPHKAP | 9.8e-08 | 2.4e-05 | 7.68 (2.98–19.80) | 0.07 | 0.01 |
| rs75639111 | TM4SF20 | 2.7e-07 | 4.4e-04 | 9.95 (2.76–35.85) | 0.03 | 0.01 |
| rs6733782 | C2orf83 | 3.6e-07 | 1.4e-03 | 3.90 (1.69–8.98) | 0.06 | 0.06 |
| rs10502901 | ACAA2 | 4.9e-07 | 7.4e-08 | 19.94 (6.70–59.30) | 0.04 | 0.08 |
| rs6760875 | SPHKAP | 5.1e-07 | 2.0e-03 | 2.11 (1.31–3.38) | 0.45 | 0.28 |
| rs10177414 | MFF | 6.1e-07 | 7.3e-03 | 1.97 (1.20–3.22) | 0.45 | 0.14 |
| rs16824283 | SPHKAP | 6.8e-07 | 3.8e-02 | 2.15 (1.04–4.43) | 0.28 | 0.06 |
| rs4530360 | SPHKAP | 7.2e-07 | 1.2e-03 | 2.47 (1.43–4.27) | 0.28 | 0.17 |
| rs73102745 | NGEF | 8.8e-07 | 1.1e-03 | 2.62 (1.47–4.67) | 0.12 | 0.14 |
Abbreviations: GT, genotype; HR, hazard ratio; MAF, minor allelic frequency; PTOT, unadjusted P value for the association with the time to prostate-specific antigen progression; SNP, single-nucleotide polymorphism.
a
MAFs represent those observed in the analysis population.