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. 2021 Oct 14;25(1):110–121. doi: 10.1007/s11307-021-01656-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4. — BP and fluorescence images were correlated to EGFR IHC on a pixel-to-pixel basis using the Pearson correlation coefficient (r). EGFR expression heterogeneity is most accurately represented by PAI determined BP. a Pixel resolution was reduced to the clinically relevant range by the image pyramid method. BP and fluorescence against IHC intensity were plotted for representative images at four image resolutions. b The r from all specimen were plotted against spatial resolution, which indicates a steady increased correlation to IHC for BP and ABY-029. c Pearson’s correlation coefficients of BP, ABY-029, and IRDye 700 with IHC at 168-μm image resolution were presented in three panels, with each line representing data from individual mouse.