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. 2021 Oct 14;25(1):110–121. doi: 10.1007/s11307-021-01656-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5. — Comparison of administration-to-imaging time for PAI and SAI. a Representative images of the xenograft FaDu model are shown for SAI and PAI at each time point. b The average signals of tumor and normal tongue for each time point were graphed. BP is fairly constant over the 5-h period, while fluorescence signal decreases for IRDye 700DX and increases for ABY-029 over time. c ROC analysis indicates diagnostic abilities of ABY-029 and BP improve over time; however, BP outperforms ABY-029 images, especially at short administration-to-imaging time points.