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. Author manuscript; available in PMC: 2022 Oct 3.
Published in final edited form as: Stat Methods Med Res. 2021 Nov 24;31(3):510–519. doi: 10.1177/09622802211055854

Figure 1.

Figure 1.

Mutation burden ratio for known driver genes of breast cancer study (BRCA) in The cancer genome atlas (TCGA). Y-axis represents the ratio of non-silent mutation burden relative to the background mutation burden; specifically, the non-silent mutation burden is calculated by the total number of non-silent mutations out of the total number of mutable bases, while the background mutation burden is estimated by MutSigCV.