Table 1.

The rejection rates of testing for subtype heterogeneity of driver genes under a variety of parameter settings. The rows are organized by the background mutation rates (λ), the proportion of subgroups (a), and the effect size of log-scaled selection pressure parameter (β₀). The columns are organized by the effect size of subtype heterogeneity (γ). The rejection rates higher than 0.8 are highlighted.

	0	γ
		log2	log4	log6	log8	log10
λ	10 × 10−7	0.00	0.41	0.85	0.93	0.95	0.99
	5 × 10−7	0.00	0.17	0.60	0.79	0.88	0.92
	2.5 × 10−7	0.01	0.04	0.35	0.51	0.64	0.73
a	0.1	0.01	0.01	0.26	0.44	0.58	0.71
	0.3	0.00	0.23	0.71	0.86	0.93	0.95
	0.5	0.00	0.38	0.84	0.94	0.97	0.99
β 0	log5	0.02	0.02	0.25	0.40	0.54	0.66
	log10	0.00	0.11	0.49	0.71	0.80	0.87
	log15	0.00	0.21	0.67	0.83	0.89	0.91
	log20	0.00	0.31	0.76	0.88	0.92	0.98
	log25	0.00	0.39	0.84	0.90	0.98	0.99