Fig. 6.
Circulating LT attenuates PMN accumulation at sites of PMA-induced inflammation.
A. Black and white photos of a single representative NECre Luc mouse with 2.5 μg PMA in 5 μl DMSO pipetted onto the ear and injected i.p. with 6.25 μg LT, overlaid with a false colour representation of photon emission intensity as indicated by the scale on the right in p s−1 cm−2 sr−1 over a 48 h time-course.
B. Comparison of left-ear luminescence over background between mice treated with the indicated amounts of i.p. LT and non-intoxicated mice. Significant differences were found between PMA and PMA + 6.25 μg LT mice at 24 (*P < 0.05) and 48 h (**P < 0.01).
C. Comparison between mice treated with PA and LF to non-intoxicated mice. No significant differences were found.
D. Luminescence was measured in the non-PMA treated right ear in an LT-intoxicated mouse at each indicated time point and compared to luminescence in the right control ear of non-intoxicated mice. n = 6 mice per condition.