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. Author manuscript; available in PMC: 2022 Oct 3.
Published in final edited form as: Transl Stroke Res. 2018 Jan 4;10(1):57–66. doi: 10.1007/s12975-017-0603-x

Fig. 7.

Fig. 7

Effect of Sirt3 inhibitor AGK7 on infarct volume and hemorrhagic transformation. a Representative images of cresyl violet (CV) staining are shown. b No dose-dependent effect of Sirt3 inhibition was seen in WT mice at 3 days after stroke. However, a higher dose (1.5 mg/kg i.p.) paradoxically increased infarct volume by ~ 10–15% as compared to vehicle and other doses in WT mice after stroke. c Both the lower and intermediate doses (0.15 and 0.5 mg/kg i.p., respectively) of inhibitor did not cause hemorrhagic transformation in WT mice; however, the higher dose (1.5 mg/kg. i.p.) led to significant (*p < 0.05 vs. veh; one-way ANOVA) hemorrhagic transformation in both WT and KO mice suggesting its off-target effect at this dose (n = 6–8/mice group; graphs show mean + S.E.M.).