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. Author manuscript; available in PMC: 2022 Oct 3.
Published in final edited form as: Transl Stroke Res. 2018 Jan 4;10(1):57–66. doi: 10.1007/s12975-017-0603-x

Fig. 8.

Fig. 8

Effect of the Sirt3 inhibitor “AGK7” on LKB1 phosphorylation (i.e., activation). Representative image and accompanying histogram show that the lower and intermediate dose (0.15 and 0.5 mg/kg i.p., respectively) of inhibitor showed a significant reduction in LKB1 phosphorylation (*p < 0.05 vs. veh; one-way ANOVA). However, a higher dose (1.5 mg/kg i.p.) paradoxically increased LKB1 phosphorylation at 3 days after stroke in WT mice (n = 6/time point/group; graphs show mean + S.E.M.).