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. 2022 Sep 27;23:e937125-1–e937125-6. doi: 10.12659/AJCR.937125

Table 1.

The revised International Workshop on Ocular Sarcoidosis criteria for the diagnosis of ocular sarcoidosis (2017).

  1. Other causes of granulomatous must be ruled out.

  2. Intraocular clinical signs suggestive of OS.
    1. Mutton-fat keratic precipitates (large and small) and/or iris nodules at papillary margin (Koeppe) or in stroma (Busacca).
    2. Trabecular meshwork nodules and/or tent-shaped peripheral anterior synechia.
    3. Snowballs/string of pearls vitreous opacities.
    4. Multiple chorioretinal peripheral lesions (active and atrophic).
    5. Nodular and/or segmental periphlebitis (±candle wax drippings) and/or macroaneurysm in an inflamed eye.
    6. Optic disc nodule(s)/granuloma(s) and/or solitary choroidal nodule.
    7. Bilateraly (assessed by opthalmological examination including ocular imaging showing subclinical inflammation).
  3. Systemic investigation results in syspected OS.
    1. Bilaterial hilar lymphadenopathy (BHL) by chest X-ray and/or chest computed CT scan.
    2. Negative tuberculin test or interferon-gamma relasing assays.
    3. Elevated serum ACE.
    4. Elevated serum lysozome.
    5. Elevated CD4/CD8 ratio (>3.5) in bronchoalveolar lavage fluid.
    6. Abnormal accumulation of gallium-67 scintigraphy or 18F-fluorodeoxyglucose position emission tomography imaging.
    7. Lymphopenia.
    8. Parenchymal lung changes consistent with sarcidosis as determined by pulmonologists or radiologoists.

  4. Diagnosti criteria.

Definite OS: diagnosis supported by biopsy with compatible uvetis.
Presumed OS: diagnosis not supported by biopsy, but BHL present with two intraocular signs.
Probable OS: diagnosis not supported by biopsy and BHL absent, but three intraocular signs and two systemic investigations selected from two to eight are present.

Reproduced from reference [14] (CC BY-NC-ND 4.0).