Table 4.
Total number and cumulative incidence of infection in each cycle.
| Cycle number | Treatment period | ||||||
|---|---|---|---|---|---|---|---|
| Early (cycles 1–3) | Intermediate (cycles 4–6) | Late (>sixth cycle) | |||||
| 1 | 2 | 3 | 4 | 5 | 6 | >6 | |
| Number of infectious events | 124 | 88 | 65 | 45 | 35 | 29 | 97 |
| Cumulative incidence of infection | 31 | 23 | 20 | 15 | 13 | 13 | 1–2 |
| Grade 4 infections, % a (N) | 15 (18/124) | 12 (11/88) | 17 (11/65) | 10 (12/45) | 14 (5/35) | 33 (9/29) | 12 (12/97) |
| p | |||||||
| Hb (g/dl) | 9.3 (8.3–10.3) | 10 (8.8–11.8) | <0.001 | ||||
| ANC (×109/l) | 0.9 (0.4–2.1) | 1.1 (0.5–2.2) | 0.09 | ||||
| Platelets (×109/l) | 63 (30–127) | 106 (45–181) | <0.001 | ||||
ANC, absolute neutrophil count; Hb, hemoglobin.
Lower row: peripheral blood counts at the beginning of cycle. Rate of grade 4 infections and infections leading to suspension of HMA treatment.
p indicates p value of difference in these values.
a
Related to number of infections in each cycle.