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. 2022 Sep 30;15:17562848221100106. doi: 10.1177/17562848221100106

Table 2.

Clinical variables associated with sorafenib-related survival on univariate analysis in patients with advanced stage HCC.

Predictor Median overall survival (months) Univariable models
Hazard ratio (95% CI) p
NAFLD versus other aetiologies 9.51 versus 7.66 0.99 (0.84–1.18) 0.98
Age (<75 versus ⩾75years) 7.79 versus 7.14 1.06 (0.97–1.16) 0.2
BCLC stage C or D versus 0, A or B 5.95 versus 10.13 1.49 (1.41–1.59) <0.001
CTP class
(B versus A)
4.51 versus 10.07 1.13 (1.06–1.19) <0.001
Tumour size ⩾7 versus  <7 cm (N = 3091) 5.36 versus 9.51 1.00 (0.93–1.09) 0.92
AFP ⩾400 versus <400 IU/dl (n = 4804) 5.76 versus 9.87 1.06 (1.00–1.13) 0.052
Cirrhosis (present/absent) 7.59 versus 11.41 1.27 (1.08–1.50) 0.005
Metastases (present/absent) 5.36 versus 8.26 1.41 (1.31–1.51) <0.001
PVT (present; N = 4582) 7.89 versus 7.43 1.00 (0.94–1.07) 0.56
Diabetes (present/absent) 7.70 versus 7.73 0.99 (0.93–1.04) 0.63
Hypertension (present/absent) 12.2 versus 13.9 1.04 (0.87–1.25) 0.65
Cardiovascular disease a
(present/absent)
6.74 versus 7.63 1.05 (0.95–1.16) 0.35
Previous treatment (yes/no) 9.67 versus 6.61 0.81 (0.76–0.86) <0.001
Starting dose (800 mg versus 400 mg) 8.09 versus 7.00 0.92 (0.86–0.97) 0.003
Dose reduction
(yes/no)
5.90 versus 8.93 0.92 (0.91–0.92) <0.001
Treatment response b
(yes/no)
8.00 versus 7.70 0.91 (0.39–2.11) 0.819
Duration of treatment N/A 0.92 (0.91–0.92) <0.001

AFP, α-fetoprotein; BCLC, Barcelona Clinic Liver Class; CI, confidence interval; CTP: Child–Turcotte–Pugh; HCC, hepatocellular carcinoma; NAFLD, nonalcoholic fatty liver disease; PVT: portal vein thrombus.

a

The impact of cardiovascular disease on sorafenib-specific survival was only assessed in the Veterans Affairs cohort.

b

Treatment response was defined as complete response, partial response or stable disease per RECIST criteria on imaging [CT quad phase or contrast-enhanced magnetic resonance imaging (MRI) of liver].