Table 1.
Profile of patients with severe sepsis in Catalonia
| Total N = 296,554 | Alive N = 238,775 | Dead N = 57,779 | |
|---|---|---|---|
| N (%) | N (%) | N (%) | |
| Sex (males) | 166,808 (56.2%) | 133,428 (55.9%) | 33,380 (57.8%) |
| Mean (SD) | Mean (SD) | Mean (SD) | |
|---|---|---|---|
| Charlson index | 5.51 (2.74) | 5.37 (2.72) | 6.08 (2.74) |
| Mean age | 72.9 (18.1) | 72.3 (18.7) | 75.2 (15.3) |
| Length of hospital stay (days) | 15.3 (24.2) | 15.5 (24.8) | 14.5 (21.6) |
| Age (years) | |||
| < 15 | 6430 (2.17%) | 5905 (2.47%) | 525 (0.91%) |
| 15–44 | 15,072 (5.08%) | 13,332 (5.58%) | 1740 (3.01%) |
| 45–64 | 47,027 (15.9%) | 38,020 (15.9%) | 9007 (15.6%) |
| 65–74 | 53,585 (18.1%) | 42,924 (18.0%) | 10,661 (18.5%) |
| 75–84 | 94,322 (31.8%) | 75,577 (31.7%) | 18,745 (32.4%) |
| > 84 | 80,118 (27.0%) | 63,017 (26.4%) | 17,101 (29.6%) |
| Comorbidities | |||
| Myocardial infarction | 12,377 (4.17%) | 9481 (3.97%) | 2896 (5.01%) |
| Congestive heart failure | 65,456 (22.1%) | 50,537 (21.2%) | 14,919 (25.8%) |
| Peripheral vascular disease | 16,134 (5.44%) | 12,452 (5.21%) | 3682 (6.37%) |
| Cerebrovascular disease | 22,538 (7.60%) | 17,568 (7.36%) | 4970 (8.60%) |
| Dementia | 23,510 (7.93%) | 18,791 (7.87%) | 4719 (8.17%) |
| COPD | 74,240 (25.0%) | 60,892 (25.5%) | 13,348 (23.1%) |
| Rheumatic diseases | 6952 (2.34%) | 5801 (2.43%) | 1151 (1.99%) |
| Peptic ulcer disease | 3512 (1.18%) | 2666 (1.12%) | 846 (1.46%) |
| Liver disease: mild | 29,962 (10.1%) | 22,517 (9.43%) | 7445 (12.9%) |
| Uncomplicated diabetes | 64,848 (21.9%) | 54,717 (22.9%) | 10,131 (17.5%) |
| Complicated diabetes | 14,909 (5.03%) | 12,689 (5.31%) | 2220 (3.84%) |
| Hemiplegia/paraplegia | 4896 (1.65%) | 3966 (1.66%) | 930 (1.61%) |
| Chronic kidney disease | 83,949 (28.3%) | 69,525 (29.1%) | 14,424 (25.0%) |
| Cancer | 41,129 (13.9%) | 29,039 (12.2%) | 12,090 (20.9%) |
| Liver disease: moderate–severe | 9121 (3.08%) | 6291 (2.63%) | 2830 (4.90%) |
| Metastasis | 15,473 (5.22%) | 9952 (4.17%) | 5521 (9.56%) |
| AIDS/HIV infection | 2781 (0.94%) | 2113 (0.88%) | 668 (1.16%) |
| ICU admissions* | 70,578 (23.8%) | 46,354 (19.4%) | 24,224 (41.9%) |
| Sepsis origins | |||
| Urinary | 113,565 (38.3%) | 99,236 (41.6%) | 14,329 (24.8%) |
| Respiratory | 96,940 (32.7%) | 76,410 (32.0%) | 20,530 (35.5%) |
| Abdominal | 31,518 (10.6%) | 24,001 (10.1%) | 7517 (13.0%) |
| Skin and soft tissues | 13,465 (4.54%) | 10,985 (4.60%) | 2480 (4.29%) |
| Endocarditis | 3789 (1.28%) | 2712 (1.14%) | 1077 (1.86%) |
| Device related | 22,063 (7.44%) | 17,968 (7.53%) | 4095 (7.09%) |
| CNS | 2457 (0.83%) | 1849 (0.77%) | 608 (1.05%) |
| Others | 9537 (3.22%) | 8175 (3.42%) | 1362 (2.36%) |
| Unspecific | 40,578 (13.7%) | 27,231 (11.4%) | 13,347 (23.1%) |
| Bacteremia | 84,191 (28.4%) | 56,291 (23.6%) | 27,900 (48.3%) |
| Total N = 296,554 | Alive | Dead | |
| Organ Dysfunction | |||
| Kidney | 168,603 (56.9%) | 135,059 (56.6%) | 33,544 (58.1%) |
| Lung | 45,016 (15.2%) | 28,734 (12.0%) | 16,282 (28.2%) |
| CNS | 61,377 (20.7%) | 53,209 (22.3%) | 8168 (14.1%) |
| Hematologic | 30,615 (10.3%) | 24,547 (10.3%) | 6068 (10.5%) |
| Cardiovascular | 71,929 (24.3%) | 46,306 (19.4%) | 25,623 (44.3%) |
| Liver | 3956 (1.33%) | 1819 (0.76%) | 2137 (3.70%) |
| Number of organ failures | |||
| 1 | 231,622 (78.1%) | 197,135 (82.6%) | 34,487 (59.7%) |
| 2 | 48,898 (16.5%) | 33,865 (14.2%) | 15,033 (26.0%) |
| 3 or more | 16,034 (5.41%) | 7775 (3.26%) | 8259 (14.3%) |
Data are presented as mean and standard deviation or %
AIDS: acquired immune deficiency syndrome, CNS: central nervous system, COPD: chronic obstructive pulmonary disease, HIV: human immunodeficiency virus, ICU: intensive care unit
ICU admissions* are estimated from invasive procedures related to organ failure management