Table 2.
Univariate and multivariate analyses of organ failure associated in-hospital mortality by year of admission in Catalonia (2005–2017)
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Year | n | Mortality | p | OR | IC95% | p |
| Respiratory failure | ||||||
| 2005 | 2662 | 38,8 | 1 | – | ||
| 2006 | 2459 | 37,8 | 0,8,555,715 | 0.755–0.970 | 0.0146 | |
| 2007 | 2643 | 39,2 | 0,89,399,059 | 0.791–1.011 | 0.0731 | |
| 2008 | 2799 | 36,2 | 0,77,898,524 | 0.690–0.880 | < 0.0001 | |
| 2009 | 2996 | 37,6 | 0,75,801,748 | 0.673–0.854 | < 0.0001 | |
| 2010 | 2816 | 36,0 | 0,69,558,657 | 0.616–0.786 | < 0.0001 | |
| 2011 | 2802 | 34,4 | 0,60,252,572 | 0.533–0.681 | < 0.0001 | |
| 2012 | 2776 | 36,0 | 0,58,824,668 | 0.520–0.665 | < 0.0001 | |
| 2013 | 2891 | 38,0 | 0,61,456,548 | 0.545–0.693 | < 0.0001 | |
| 2014 | 2642 | 34,3 | 0,51,394,317 | 0.453–0.583 | < 0.0001 | |
| 2015 | 2745 | 35,8 | 0,52,879,873 | 0.468–0.598 | < 0.0001 | |
| 2016 | 3380 | 32,7 | 0,46,018,306 | 0.408–0.518 | < 0.0001 | |
| 2017 | 3849 | 34,3 | 0,48,323,359 | 0.431–0.542 | < 0.0001 | |
| 2018 | 3742 | 37,9 | < 0.0001 | 0,56,156,227 | 0.501–0.630 | < 0.0001 |
| 2019 | 3814 | 35,0 | 0,4,733,619 | 0.422–0.531 | < 0.0001 | |
| AUC ROC | ||||||
| 0.762 (0.758 – 0.767) | ||||||
| Cardiovascular failure | ||||||
| 2005 | 2491 | 47,3 | 1 | – | ||
| 2006 | 2858 | 45,7 | 0,69,393,529 | 0.615–0.783 | < 0.0001 | |
| 2007 | 3225 | 45,7 | 0,69,297,304 | 0.616–0.779 | < 0.0001 | |
| 2008 | 3568 | 40,8 | 0,55,888,678 | 0.498–0.627 | < 0.0001 | |
| 2009 | 3945 | 40,5 | 0,54,844,547 | 0.490–0.614 | < 0.0001 | |
| 2010 | 4081 | 39,4 | 0,48,303,417 | 0.431–0.541 | < 0.0001 | |
| 2011 | 4487 | 37,1 | 0,44,050,755 | 0.394–0.493 | < 0.0001 | |
| 2012 | 4520 | 37,1 | 0,40,863,827 | 0.365–0.457 | < 0.0001 | |
| 2013 | 4774 | 35,5 | 0,37,430,685 | 0.335–0.418 | < 0.0001 | |
| 2014 | 4802 | 32,8 | 0,33,977,245 | 0.304–0.380 | < 0.0001 | |
| 2015 | 5256 | 32,7 | 0,32,401,597 | 0.290–0.362 | < 0.0001 | |
| 2016 | 6389 | 29,6 | 0,27,741,318 | 0.249–0.309 | < 0.0001 | |
| 2017 | 5791 | 29,9 | 0,25,132,744 | 0.225–0.281 | < 0.0001 | |
| 2018 | 7504 | 33,0 | < 0.0001 | 0,32,937,548 | 0.297–0.366 | < 0.0001 |
| 2019 | 8238 | 31,2 | 0,3,003,618 | 0.271–0.333 | < 0.0001 | |
| AUC ROC | ||||||
| 0.764 (0.761 – 0.768) | ||||||
| CNS failure | ||||||
| 2005 | 1809 | 16,2 | 1 | – | ||
| 2006 | 1676 | 16,2 | 1,003,113,881 | 0.827–1.217 | 0.9749 | |
| 2007 | 2036 | 15,1 | 0,984,914,164 | 0.818–1.186 | 0.8727 | |
| 2008 | 2392 | 12,9 | 0,783,057,153 | 0.651–0.941 | 0.0092 | |
| 2009 | 2648 | 15,9 | 0,983,827,452 | 0.826–1.171 | 0.8547 | |
| 2010 | 2865 | 13,1 | 0,821,556,085 | 0.689–0.980 | 0.0292 | |
| 2011 | 3197 | 12,4 | 0,727,698,472 | 0.611–0.866 | 0.0003 | |
| 2012 | 3860 | 12,3 | 0,676,469,996 | 0.571–0.801 | < 0.0001 | |
| 2013 | 3855 | 12,5 | 0,703,124,481 | 0.594–0.832 | < 0.0001 | |
| 2014 | 4237 | 11,4 | 0,65,610,759 | 0.555–0.776 | < 0.0001 | |
| 2015 | 4704 | 10,4 | 0,55,191,349 | 0.467–0.652 | < 0.0001 | |
| 2016 | 6238 | 12,0 | 0,569,267,239 | 0.486–0.667 | < 0.0001 | |
| 2017 | 7081 | 13,7 | 0,624,865,732 | 0.536–0.729 | < 0.0001 | |
| 2018 | 7542 | 14,2 | < 0.0001 | 0,673,377,407 | 0.578–0.784 | < 0.0001 |
| 2019 | 7237 | 14,7 | 0,64,039,723 | 0.549–0.746 | < 0.0001 | |
| AUC ROC | ||||||
| 0.761 (0.755 – 0.766) | ||||||
| Hematological failure | ||||||
| 2005 | 1089 | 21,7 | 1 | – | ||
| 2006 | 1122 | 22,4 | 1,02,282,062 | 0.808–1.295 | 0.8513 | |
| 2007 | 1218 | 23,0 | 1,03,249,027 | 0.819–1.301 | 0.7866 | |
| 2008 | 1304 | 20,6 | 0,85,500,995 | 0.679–1.077 | 0.1829 | |
| 2009 | 1578 | 21,2 | 0,80,145,653 | 0.643–0.999 | 0.0492 | |
| 2010 | 1705 | 21,7 | 0,81,385,536 | 0.655–1.011 | 0.0625 | |
| 2011 | 1814 | 20,8 | 0,7,338,104 | 0.592–0.910 | 0.0048 | |
| 2012 | 1931 | 20,2 | 0,67,176,921 | 0.542–0.832 | 0.0003 | |
| 2013 | 2141 | 18,4 | 0,56,482,716 | 0.457–0.698 | < 0.0001 | |
| 2014 | 2060 | 17,3 | 0,52,934,679 | 0.426–0.657 | < 0.0001 | |
| 2015 | 2239 | 18,0 | 0,56,450,526 | 0.457–0.697 | < 0.0001 | |
| 2016 | 2822 | 17,7 | 0,4,413,267 | 0.360–0.542 | < 0.0001 | |
| 2017 | 2883 | 20,3 | 0,45,095,202 | 0.368–0.552 | < 0.0001 | |
| 2018 | 3327 | 20,2 | < 0.0001 | 0,529,861 | 0.435–0.646 | < 0.0001 |
| 2019 | 3382 | 19,2 | 0,47,667,204 | 0.391–0.581 | < 0.0001 | |
| AUC ROC | ||||||
| 0.835 (0.829 – 0.840) | ||||||
| Liver failure | ||||||
| 2005 | 80 | 36,2 | 1 | – | ||
| 2006 | 96 | 54,2 | 1,83,497,874 | 0.892–3.776 | 0.0992 | |
| 2007 | 119 | 61,3 | 1,96,503,495 | 0.995–3.882 | 0.0518 | |
| 2008 | 107 | 40,2 | 0,85,993,432 | 0.430–1.721 | 0.6698 | |
| 2009 | 147 | 59,9 | 2,07,901,315 | 1.072–4.032 | 0.0304 | |
| 2010 | 149 | 64,4 | 1,93,607,915 | 0.998–3.754 | 0.0505 | |
| 2011 | 186 | 44,6 | 0,95,603,365 | 0.506–1.805 | 0.8898 | |
| 2012 | 240 | 55,8 | 1,35,968,041 | 0.736–2.513 | 0.3269 | |
| 2013 | 252 | 55,6 | 1,31,101,581 | 0.712–2.415 | 0.3848 | |
| 2014 | 250 | 61,6 | 1,31,593,221 | 0.712–2.434 | 0.3815 | |
| 2015 | 371 | 59,3 | 1,22,325,659 | 0.678–2.208 | 0.5035 | |
| 2016 | 365 | 56,2 | 0,97,385,455 | 0.540–1.756 | 0.9298 | |
| 2017 | 382 | 58,9 | 0,96,491,164 | 0.534–1.744 | 0.9059 | |
| 2018 | 514 | 48,8 | < 0.0001 | 0,72,797,746 | 0.400–1.326 | 0.2992 |
| 2019 | 698 | 49,3 | 0,68,868,416 | 0.383–1.239 | 0.2134 | |
| AUC ROC | ||||||
| 0.801 (0.788 – 0.815) | ||||||
| Kidney failure | ||||||
| 2005 | 4780 | 25,9 | 1 | – | ||
| 2006 | 4937 | 26,1 | 0,940,454,002 | 0.850–1.040 | 0.2332 | |
| 2007 | 5195 | 26,2 | 0,923,138,453 | 0.836–1.020 | 0.1160 | |
| 2008 | 5930 | 25,3 | 0,873,826,895 | 0.793–0.963 | 0.0065 | |
| 2009 | 7090 | 24,2 | 0,830,444,748 | 0.756–0.912 | 0.0001 | |
| 2010 | 8326 | 22,9 | 0,758,868,867 | 0.692–0.832 | < 0.0001 | |
| 2011 | 10,341 | 20,5 | 0,659,592,374 | 0.603–0.721 | < 0.0001 | |
| 2012 | 12,025 | 19,4 | 0,609,565,863 | 0.558–0.665 | < 0.0001 | |
| 2013 | 12,980 | 18,2 | 0,53,201,268 | 0.488–0.580 | < 0.0001 | |
| 2014 | 13,721 | 17,9 | 0,535,202,205 | 0.491–0.584 | < 0.0001 | |
| 2015 | 14,896 | 18,2 | 0,531,784,828 | 0.488–0.579 | < 0.0001 | |
| 2016 | 15,659 | 17,3 | 0,456,185,713 | 0.419–0.497 | < 0.0001 | |
| 2017 | 17,538 | 18,1 | 0,465,317,937 | 0.428–0.506 | < 0.0001 | |
| 2018 | 17,311 | 19,2 | < 0.0001 | 0,511,196,703 | 0.470–0.556 | < 0.0001 |
| 2019 | 17,874 | 18,5 | 0,45,881,633 | 0.422–0.499 | < 0.0001 | |
| AUC ROC | ||||||
| 0.783 (0.780 – 0.786) | ||||||
Data are presented as number of death or %. The multivariate analysis is adjusted by sex, age group, comorbidities, ICU admission, emergency admission, organ dysfunction, number of organ failures, sepsis origin and bacteremia
CI confidence interval, ICU intensive care unit, OR odds ratio, NS non-significant