Table 1.

Regulators of mitochondrial fission or fusion in breast cancer cells

Regulators	Cell line	Fission/fusion	Roles	References
Hypoxia	MDA-MB-231	Fission↑	Migration↑	[27]
GBP2	MDA-MB-231 and MDA-MB-436	Fission↓	Migration↓ and invasion↓	[32]
MARCH5	MDA-MB-231 and MDA-MB-468	Fission↑	Migration↑and metastasis↑	[33]
PISD	SUM159 and MDA-MB-231-PISD	Fission↑	Migration↑, OXPHOS↑	[34]
BRCA1	MDA-MB-231	Fusion↓	Migration↓, proliferation↓, and metastasis↓	[35]
RACGAP1/LncRNA RACGAP1	MCF7 and MDA-MB-231	Fission↑, Fusion↓	Migration↑, glycolysis↑, and metastasis↑	[6]
CaMKII	MDA-MB-231	Fission↑	Apoptosis↑ and ROS↑	[36]
MiR-195	MCF-7 and MDA-MB-231	Fission↑, Fusion↓	Apoptosis↑	[37]
Mdivi-1	MCF-7 and MDA-MB-231	Fission↓	Apoptosis↓, OXPHOS↓, ATP↓	[38, 39]
MiDs	MCF7	Fission↑ and Fusion↓	Proliferation↑and apoptosis↓	[40]
MiRNA 148/152	MDA-MB-231	Fission↑	Proliferation↑	[41]
MTFR2	Hs578T, MDA-MB-231, and MCF-7	Fission↑	Proliferation↑, invasion↑ and glycolysis↑	[42]
IR-783	MDA-MB-231 and MCF-7	Fission↑	Proliferation↓, migration↓, and ATP↓	[43]
PKM2	MCF-7	Fusion↑	mtDNA↑and ATP↓	[30]
Polyphyllin I	MCF-7 and MDA-MB-231	Fission↑	Apoptosis↑, cytochrome c↑, and mitophagy↑	[44]
Silibinin	MDA-MB-231	Fusion↑	Proliferation↓, migration↓, and invasion↓	[38]
Luteolin	4T1 and MDA-MB-231	Fission↓	Apoptosis↑ and metastasis↓	[45]
Cepharanthin	MDA-MB-231 and BT549	Fission↑	Apoptosis↑and autophagy↓	[46]