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. 2022 Oct 2;20:445. doi: 10.1186/s12967-022-03645-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The characterization of ubiquitinome of CRC cells and the identification of ubiquitin-binding motifs in colonic cells. A The numbers of proteins with more than 10 ubiquitin-modified sites or with less than 10 ubiquitin-modified sites (each circle represented 20 proteins). B Highly ubiquitinated proteins (n ≥ 10) and the numbers of ubiquitin-modified sites. (C–E) GO analyses uncovered the specific modules that the highly-ubiquitinated proteins enriched in. F KEGG analyses uncovered the specific modules that the highly-ubiquitinated proteins enriched in. G The top five ubiquitin-binding motifs. The height of each letter corresponded to the frequency of this amino acid residue in the position. The central K refers to the ubiquitinated Lys. H The motif scores of the top five ubiquitination motifs. I The numbers of peptides covered by the motifs