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. 2022 Oct 2;20:445. doi: 10.1186/s12967-022-03645-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The ubiquitination of FOCAD at Lys583, Lys587 was probably relevant to the progression of CRC. (A–B) The protein expression of FOCAD and DOCK₂ in cancerous and para-cancerous colonic tissues of CRC patients. (C–D) The survival analysis of FOCAD and DOCK₂ using the proteomic datasets from CPTAC. (E–F) The increased ubiquitinated sites of FOCAD and DOCK₂ in CRC cells. (G–H) The mRNA expression of FOCAD and DOCK₂ in cancerous and para-cancerous colonic tissues of CRC patients. (I–J) The correlation between the mRNA and protein levels of FOCAD and DOCK₂ in individuals, as analyzed using the datasets from the cbioportal database. (K–L) The protein expression of FOCAD in normal colonic tissues and CRC tissues