Table 1.
Serum biochemistries in wild-type and Spp1−/− mice with and without CKD
| Control | CKD—Adenine | CKD—Aristolochic Acid | ||||
|---|---|---|---|---|---|---|
| Parameter | Wild Type | Spp1−/− | Wild Type | Spp1−/− | Wild Type | Spp1−/− |
| Serum Phos (mg/dl) | 6.6±0.5 | 6.6±1.3 | 9.9±3.3b | 11.6±2.8b | 11.0±3.3b | 8.6±2b |
| Serum Ca (mg/dl) | 8.6±0.2 | 8.6±0.2 | 9.4±0.6b | 8.7±0.5a | 9.3±0.5 | 9.4±0.6b |
| PTH (pg/ml) | 685.7 | 617.1 | 1850.4 | 2449.6 | 1374.3 | 1905.5 |
| (569.1–908.2) | (446.3–1152.4) | (654.8–3071.1) | (1864.7–3529.5)b | (634.8–2079.2) | (1278–4766.6)b | |
| FGF23 (pg/ml) | 647.4 | 544.5 | 13,329.9 | 8021.8 | 8470.7 | 10,095.7 |
| (523.9–713.2) | (362.8–733.3) | (6369.8–20,416.4)b | (5080–13,992.4)b | (4478.2–14,691.9)b | (7427.3–21,706.7)b | |
| BUN (mg/dl) | 24.6±3.7 | 25.4±2.9 | 42.9±7.1b | 52.2±10.9b | 44.7±23.6b | 37.5±17.5b |
All normally distributed parameters are presented as mean±SD, non-normally distributed parameters (FGF23 and PTH) are presented as median (interquartile range); n≥7 mice per group for each time point. Group differences were analyzed by one-way ANOVA with multiple comparisons. Phos, phosphorus; Ca, calcium; PTH, parathyroid hormone; FGF23, fibroblast growth factor 23; Spp1−/−, OPN-null mice.
a
Statistically different (P<0.05) compared with WT in same group.
b
Statistically different (P<0.05) compared with mice of same genotype in control (non-CKD) group.