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. 2022 Sep 30;10(9):e004790. doi: 10.1136/jitc-2022-004790

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Identification of HLA-A*11:01-restricted T-cell epitopes of HPV16 E6 and E7. (A) Naïve CD8⁺ T cells were isolated from HLA-A*11:01-positive, healthy donors and stimulated with indicated E6 or E7 peptides. After approximately 14 days in culture, stimulated T cells were stained with the corresponding tetramer. The representative tetramer staining flow plots of peptide stimulated CD8⁺ T cells from healthy donors are shown. The underlined number is the percentage of gated tetramer⁺CD8⁺ cells. (B) Recognition of SK-MEL-28-E6 (E6⁺) or SK-MEL-28-E7 (E7⁺) tumor cells by TTL, IVC, and LLI-specific polyclonal T cells was determined by IFN-γ ELISpot. Peptide-pulsed T2-A11 served as positive controls. IFN-γ, interferon gamma; ELISpot, enzyme-linked immunospot; SFU, spot-forming unit.