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. Author manuscript; available in PMC: 2022 Oct 3.
Published in final edited form as: J Bone Miner Res. 2013 Sep;28(9):1962–1974. doi: 10.1002/jbmr.1935

Fig. 1.

Fig. 1.

Lrrk1−/− mice have increased bone mineral density (BMD). (A) KO of Lrrk1 results in the highest observed vBMD among 3629 KO mouse lines. A histogram of the 14-week-old homozygous to WT mouse vBMD ratio is plotted with vBMD ratio data from 3629 distinct KO mouse lines compared to WT littermate mice, measured by DXA. (B) Total body BMD is increased in 6-week-old Lrrk1 KO mice. Values are expressed as mean ± SEM. A star represents statistical significance in Lrrk1−/− mice compared to the corresponding littermate controls (p < 0.01, n = 8). (C) Total body BMD, vertebra BMD, and femur BMD are increased in 70-week-old male mice. Values are expressed as mean ± SEM. A star represents statistical significance in Lrrk1 KO mice compared to the corresponding littermate controls (p < 0.01, n = 9).