Lrrk1 KO mice are protected against OVX-induced bone loss. (A) Time-course of spine BMD at baseline and 4, 8, and 12 weeks after surgery at 16 weeks of age (n = 4). Changes in spin BMD (B), total body BMD (C), and femur BMD (D) 12 weeks after surgery. μCT analyses of femoral neck BV/TV (E), L5 mid-region trabecular BV/TV (F), and tibia shaft cortical thickness (G) 12 weeks after surgery. Data are means ± SEM for 11 or 12 mice per group. Single and double asterisks indicate significant differences in OVX mice compared with control sham mice at p < 0.01 and p < 0.05, respectively.