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. 2022 Oct 3;13:5814. doi: 10.1038/s41467-022-33030-4

Fig. 4. Therapeutic efficacy of Ab 12 IgG and Ab 2-7 scFv-Fc in Syrian golden hamster model.

Fig. 4

A Therapeutic treatment of Syrian golden hamsters post-infection with Ab 12 IgG or Ab 2-7 scFv-Fc leads to a 513.9- and 5.2-fold reduction of viral loads, respectively, compared to control (PBS) treated animals B Pathology scores for animals treated with PBS, Ab 12 IgG, or Ab 2-7 scFv-Fc. Significant reduction in overall, consolidation, and septal thickening scores were seen for Ab 12 treatment. Scores were determined based on the criteria in Supplementary Table 2. Data points represent individual mice with geometric mean (A) or mean ± standard deviation in (B). Statistical analysis was performed using Mann–Whitney test in (A) and Kruskall–Wallis test with Dunn’s post-hoc correction in (B). Source data are provided as a Source Data file.