Table 4.
Changes in Coagulation Profile Among Oral Contraceptive Users
| Profile | Type of OC Used | Result | Conclusion | Author | |
|---|---|---|---|---|---|
| OC Users | Non-Users | ||||
| PT in second | COC | 11.46 | 13.79 | Decrease | [65] |
| COC | - | - | Decrease | [67] | |
| COC | 13.4 | 13.6 | Decrease | [73] | |
| COC | 12.8 ± 1.5 | 13.7 ± 2.05 | Decrease | [75] | |
| COC | 10.35 | 10.78 | Decrease | [46] | |
| Both | 14 | 13.4 | No difference | [77] | |
| Not indicated | 14.8 ± 1.2 | 14.8 ± 2.1 | No difference | [76] | |
| COC | 11.8 ± 2.27 | 12.4 ± 1.08 | No difference | [69] | |
| Not indicated | 14 | 13.5 | No difference | [79] | |
| APTT in second | COC | 27.99 | 32.49 | Decrease | [65] |
| COC | 40.9 | 41.9 | Decrease | [73] | |
| COC | 32.6 ± 1.92 | 33.7 ± 1.52 | Decrease | [75] | |
| COC | 25.9 ± 2.61 | 28.3 ± 2.76 | Decrease | [69] | |
| Not indicated | 31.3 | 33 | Decrease | [79] | |
| Not indicated | 33.1 ± 3.9 | 34.3 ± 4.9 | No difference | [76] | |
| COC | - | - | No difference | [67] | |
| COC | 29.83 | 30.46 | No difference | [46] | |
| TT in second | COC | 17.57 | 20.45 | Decrease | [65] |
| COC | - | - | Decrease | [67] | |
| COC | 11.9 ± 1.81 | 12.6 ± 1.27 | Decrease | [75] | |
| Both | 9.1 | 9.8 | Decrease | [77] | |
| Fibrinogen in mg/dl | COC | 387.10 | 276.85 | Increase | [65] |
| COC | - | - | Increase | [67] | |
| COC | 625 | 260 | Increase | [74] | |
| COC | 347 ± 80.9 | 305.9 ± 45.99 | Increase | [75] | |
| COC | 327.47 | 296.57 | Increase | [46] | |
| Not indicated | 161.4 ± 64.3 | 161 ± 71 | No difference | [76] | |
| Both | 266 | 249 | No difference | [77] | |
| D-dimer in ng/mL | COC | 813.36 | 257.04 | Increase | [65] |
| Not indicated | 1000 | Negative | Increase | [79] | |
| COC | 350 ± 0.07 | 210± 0.07 | Increase | [83] | |
Notes: Negative D-dimer value is when the D-dimer level is below a predetermined cut-off threshold. The conclusions are derived from the respective authors listed.