Comparison 3. Monoamine modulators versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Weight: average endpoint/change in body weight	3	103	Mean Difference (IV, Random, 95% CI)	‐1.89 [‐3.31, ‐0.47]
3.1.1 Reboxetine	2	79	Mean Difference (IV, Random, 95% CI)	‐1.90 [‐3.07, ‐0.72]
3.1.2 Fluoxetine	1	24	Mean Difference (IV, Random, 95% CI)	6.40 [‐7.56, 20.36]
3.2 Weight: average endpoint/change in body mass index (BMI)	3	103	Mean Difference (IV, Random, 95% CI)	‐0.66 [‐1.05, ‐0.26]
3.2.1 Reboxetine	2	79	Mean Difference (IV, Random, 95% CI)	‐0.68 [‐1.08, ‐0.28]
3.2.2 Fluoxetine	1	24	Mean Difference (IV, Random, 95% CI)	1.10 [‐2.35, 4.55]
3.3 Leaving the study early: for any reason	3	115	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.56, 1.94]
3.3.1 Reboxetine	2	85	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.47, 1.82]
3.3.2 Fluoxetine	1	30	Risk Ratio (M‐H, Random, 95% CI)	2.00 [0.43, 9.32]
3.4 Mental state: SANS (higher = worse)	3	103	Mean Difference (IV, Random, 95% CI)	‐0.14 [‐1.98, 1.71]
3.4.1 Reboxetine	2	79	Mean Difference (IV, Random, 95% CI)	‐0.56 [‐2.67, 1.55]
3.4.2 Fluoxetine	1	24	Mean Difference (IV, Random, 95% CI)	1.24 [‐2.54, 5.02]
3.5 Mental state: SAPS (higher = worse)	3	103	Mean Difference (IV, Random, 95% CI)	0.09 [‐2.01, 2.19]
3.5.1 Reboxetine	2	79	Mean Difference (IV, Random, 95% CI)	‐2.42 [‐8.87, 4.04]
3.5.2 Fluoxetine	1	24	Mean Difference (IV, Random, 95% CI)	1.09 [‐0.36, 2.54]
3.6 Mental state: CGI (higher = worse)	2	79	Mean Difference (IV, Random, 95% CI)	0.13 [‐0.28, 0.54]
3.6.1 Reboxetine	2	79	Mean Difference (IV, Random, 95% CI)	0.13 [‐0.28, 0.54]
3.7 Mental state: HAM‐D (higher = worse)	2	79	Mean Difference (IV, Random, 95% CI)	‐2.12 [‐4.22, ‐0.01]
3.7.1 Reboxetine	2	79	Mean Difference (IV, Random, 95% CI)	‐2.12 [‐4.22, ‐0.01]
3.8 Adverse effects	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.8.1 Neurological: change in BAS	1	59	Mean Difference (IV, Random, 95% CI)	‐0.18 [‐0.65, 0.29]
3.8.2 Neurological: change in SAS	1	59	Mean Difference (IV, Random, 95% CI)	0.26 [‐1.00, 1.52]
3.8.3 Gastrointestinal: increased appetite	1	59	Mean Difference (IV, Random, 95% CI)	‐0.68 [‐1.19, ‐0.17]