| 4.1 Weight: average endpoint/change in body weight |
3 |
168 |
Mean Difference (IV, Random, 95% CI) |
‐4.82 [‐9.99, 0.35] |
| 4.2 Weight: average endpoint/change in body mass index |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐2.68 [‐4.10, ‐1.26] |
| 4.3 Leaving the study early: for any reason |
2 |
132 |
Risk Ratio (M‐H, Random, 95% CI) |
1.09 [0.85, 1.41] |
| 4.4 Reports of nausea |
2 |
120 |
Risk Ratio (M‐H, Random, 95% CI) |
1.20 [0.26, 5.44] |
| 4.5 Mental state |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 4.5.1 Average score: PANSS general psychopathology scale (higher = worse) |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐1.53 [‐2.16, ‐0.90] |
| 4.5.2 Average score: PANSS positive (higher = worse) |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐0.46 [‐1.02, 0.09] |
| 4.5.3 Average score: PANSS negative (higher = worse) |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐0.35 [‐0.79, 0.08] |
| 4.5.4 Average score: PANSS total (higher = worse) |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐2.08 [‐3.07, ‐1.10] |
| 4.6 Adverse effects |
2 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 4.6.1 Gastrointestinal: constipation |
1 |
67 |
Risk Ratio (M‐H, Random, 95% CI) |
0.21 [0.03, 1.67] |
| 4.6.2 Gastrointestinal: dry mouth |
2 |
120 |
Risk Ratio (M‐H, Random, 95% CI) |
0.61 [0.27, 1.37] |
| 4.6.3 Gastrointestinal: increased appetite |
2 |
120 |
Risk Ratio (M‐H, Random, 95% CI) |
0.26 [0.10, 0.66] |
| 4.6.4 Gastrointestinal: nausea/vomiting/diarrhoea |
1 |
67 |
Risk Ratio (M‐H, Random, 95% CI) |
3.09 [0.34, 28.23] |
| 4.6.5 Gastrointestinal: weight gain |
2 |
120 |
Risk Ratio (M‐H, Random, 95% CI) |
0.14 [0.07, 0.26] |
| 4.6.6 Neurological: asthenia |
1 |
67 |
Risk Ratio (M‐H, Random, 95% CI) |
0.90 [0.37, 2.20] |
| 4.6.7 Neurological: concentration/attention/memory difficulty |
2 |
120 |
Risk Ratio (M‐H, Random, 95% CI) |
8.97 [1.17, 68.63] |
| 4.6.8 Neurological: dizziness |
2 |
120 |
Risk Ratio (M‐H, Random, 95% CI) |
0.41 [0.18, 0.91] |
| 4.6.9 Neurological: fatigue |
2 |
120 |
Risk Ratio (M‐H, Random, 95% CI) |
1.02 [0.53, 1.96] |
| 4.6.10 Neurological: insomnia |
1 |
67 |
Risk Ratio (M‐H, Random, 95% CI) |
0.52 [0.05, 5.41] |
| 4.6.11 Neurological: paraesthesia |
1 |
67 |
Risk Ratio (M‐H, Random, 95% CI) |
7.21 [0.39, 134.32] |
| 4.6.12 Neurological: psychomotor slowing |
1 |
67 |
Risk Ratio (M‐H, Random, 95% CI) |
9.26 [0.52, 165.60] |
| 4.6.13 Neurological: somnolence |
1 |
67 |
Risk Ratio (M‐H, Random, 95% CI) |
1.23 [0.88, 1.70] |
| 4.7 Physiological: cardiovascular measures |
1 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 4.7.1 Cardiovascular measure: diastolic blood pressure [mm Hg] |
1 |
67 |
Mean Difference (IV, Random, 95% CI) |
‐3.47 [‐6.12, ‐0.82] |
| 4.7.2 Cardiovascular measure: systolic blood pressure [mm Hg] |
1 |
67 |
Mean Difference (IV, Random, 95% CI) |
‐4.62 [‐8.14, ‐1.10] |
| 4.8 Physiological: laboratory measures |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 4.8.1 Fasting blood glucose (mg/dL) |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐9.22 [‐12.59, ‐5.86] |
| 4.8.2 HDL cholesterol (mg/dL) |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.36 [‐1.59, 2.31] |
| 4.8.3 Insulin (ulU/mL) |
1 |
67 |
Mean Difference (IV, Random, 95% CI) |
‐0.04 [‐3.66, 3.58] |
| 4.8.4 Insulin resistance Index |
1 |
67 |
Mean Difference (IV, Random, 95% CI) |
‐0.27 [‐1.10, 0.56] |
| 4.8.5 LDL cholesterol (mg/dL) |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐7.99 [‐21.82, 5.84] |
| 4.8.6 Leptin (ng/mL) |
1 |
67 |
Mean Difference (IV, Random, 95% CI) |
‐3.84 [‐8.52, 0.84] |
| 4.8.7 Total cholesterol (mg/dL) |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐11.69 [‐31.86, 8.48] |
| 4.8.8 Triglycerides (mg/dl) |
2 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐5.12 [‐18.70, 8.46] |
| 4.8.9 VLDL cholesterol (mg/dL) |
1 |
67 |
Mean Difference (IV, Random, 95% CI) |
‐1.30 [‐6.09, 3.49] |
