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. 2022 Oct 3;2022(10):CD013337. doi: 10.1002/14651858.CD013337.pub2

Comparison 7. Olanzapine/samidorphan versus olanzapine only.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
7.1 Weight: clinically important change in weight > 10% 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
7.2 Weight: clinically important change in weight > 7% 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
7.3 Weight: average endpoint/change in body weight (kg) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.4 Weight: average endpoint/change in waist circumference 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.5 Leaving the study early: for any reason 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
7.6 Mental state 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.6.1 Average score: PANSS total (higher = worse) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.6.2 Average score: CGI (higher = worse) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.7 Physiological: laboratory measures 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.7.1 Fasting blood glucose (mg %) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.7.2 HDL cholesterol (mg %) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.7.3 Insulin (ulU/mL) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.7.4 LDL cholesterol (mg/dL) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.7.5 Total cholesterol (mg/dL) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.7.6 Triglycerides (mg /dL) 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.7.7 HbA1c [%] 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.8 Adverse events 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
7.8.1 Weight increased 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
7.8.2 Somnolence 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
7.8.3 Dry mouth 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected
7.8.4 Increased appetite 1   Risk Ratio (M‐H, Random, 95% CI) Totals not selected