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. 2022 Oct 3;2022(10):CD013337. doi: 10.1002/14651858.CD013337.pub2

Sun 2007.

Study characteristics
Methods Randomisation: randomised, digital table
Blinding: double‐blind, participant, investigator
Duration: 10 weeks
Country: no details
Participants Diagnosis: schizophrenia (CCMD‐3)
Age: 19‐48 years
Sex: male and female
Setting: no details
Excluded: nervous system disorders and other mental illnesses; obesity disorders, history of diabetes, hypertension, heart disease; drug or alcohol dependence
Interventions
  1. Ranitidine (300 mg/d) + olanzapine; N = 33

  2. Placebo + olanzapine; N = 32

Outcomes Able to use:
  1. Primary outcomes

    1. Weight measures

      1. Body weight

      2. BMI

      3. Waist circumference

      4. Waist to hip ratio

    2. Mental state

      1. PANSS

Notes This study was translated from Chinese using an app
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomisation using digital table method
Allocation concealment (selection bias) Unclear risk Allocation concealment not indicated
Blinding of participants and personnel (performance bias)
All outcomes Low risk Double‐blind (participant, investigator)
Blinding of outcome assessment (detection bias)
All outcomes Low risk Outcome unlikely to be biased by blinding
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Loss to follow‐up not indicated
Selective reporting (reporting bias) Low risk Study protocol unavailable, but all metabolic measures indicated in methods section were reported on
Other bias Low risk No obvious bias