Fig 6.

Dependence of the SIPAct level on the VWF multimer size in P1 (A) and P2 (B) AVFs. The results are obtained at AVF flow rates ($Q_v^{out},$ Eq (7)) of 300 mL/min (dashed line) and 725 mL/min (solid line) for the first patient. The first value corresponds to the minimum flow rate required for effective haemodialysis. The second value represents the maximum AVF P1 flow rate used in the calculations. The results are obtained at AVF flow rates of 736 mL/min (dashed line) and 1300 mL/min (solid line) for the second patient. The first value corresponds to the flow rate when SIPAct is absent for the lowest VWF multimer size within the considered range (N = 10). The second value is the maximum AVF flow rate used in this work for the second patient. The solid and dashed lines are to guide the eye.