Table 3.

Multivariate Cox Regression Analysis for OS

		Multivariate Analysis
		Model 1		Model 2
Characteristics		HR (95% CI)	p- value	HR (95% CI)	p- value
∆CEA%	< −30.29% vs > −30.29%	0.558 (0.259–1.201)	0.136
∆CA199%	< 20.30% vs > 20.30%	0.468 (0.220–0.994)	0.048
STBC score	0 vs 1–2			0.204 (0.078–0.532)	0.001
ypT staging	(0–2) vs (3–4)	0.420 (0.182–0.970)	0.042	0.426 (0.184–0.986)	0.046
ypN staging	Negative vs positive	0.680 (0.315–1.465)	0.324	0.574 (0.269–1.226)	0.152

Notes: Model 1, ∆CEA% and ∆CA199% were included in multivariate analysis, STBC score was not. Model 2: STBC score was in multivariate analysis, ∆CEA% and ∆CA199% were not.

Abbreviations: yp, pathologic status after neoadjuvant chemoradiotherapy; ∆CEA %, (post-chemoradiotherapy CEA – pre-chemoradiotherapy CEA)/pre-chemoradiotherapy CEA*100%; ∆CA199 %, (post-chemoradiotherapy CA199 – pre-chemoradiotherapy CA199)/ pre-chemoradiotherapy CA199*100%; STBC score, serum tumor biomarkers change score.