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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Plast Reconstr Surg. 2021 Sep 28;150:12S–19S. doi: 10.1097/PRS.0000000000009668

Figure 1: Schematic of skin aging and senotherapeutic treatment.

Figure 1:

Skin aging is associated with many phenotypic alterations including increased permeability and stiffness of the stratum corneum, flattening and loss of rete ridges in the epidermal-derma junction, alterations in cellular composition, increased senescence cell burden and other aging phenotypes that reduces the protective function and wound healing of the skin. However, senotherapeutic treatments that selectively target senescent cells promoting their clearance (senolysis) or suppression of their SASP (senostasis) decreases inflammation, attenuates tissue dysfunction, and improves regenerative capacity in skin.