Table 4.

List of lipoprotein fractions/subfractions and inflammatory cytokines and chemokines contributing to the orthogonal partial least squares discriminant analysis model depicted in Figure 3.

Lipoprotein/cytokine	Description	VIP	P(corr)	Upregulated or downregulated in patients
MIP3β	Cytokine	1.44	−0.80	↑
IFNα2a	Cytokine	1.36	−0.75	↑
L3PL	Phospholipids	1.35	0.71	↓
L2PL	Phospholipids	1.35	0.65	↓
L2CH	Cholesterol	1.34	0.65	↓
L3CH	Cholesterol	1.34	0.70	↓
L2AB	Apo-B	1.33	0.65	↓
L2PN	Particle number	1.33	0.65	↓
L2FC	Free cholesterol	1.26	0.56	↓
IL-18	Cytokine	1.23	−0.67	↑
L3AB	Apo-B	1.22	0.64	↓
L3PN	Particle number	1.22	0.64	↓
L4CH	Cholesterol	1.22	0.66	↓
L4FC	Free cholesterol	1.17	0.64	↓
H4PL	Phospholipids	1.17	0.61	↓
GRO-α	Cytokine	1.15	0.62	↓
L1CH	Cholesterol	1.14	0.60	↓
L3FC	Free cholesterol	1.14	0.50	↓
L4PL	Phospholipids	1.14	0.62	↓
ENA-78	Cytokine	1.11	0.61	↓
L1FC	Free cholesterol	1.10	0.54	↓
L1PL	Phospholipids	1.07	0.56	↓
LDFC	Free cholesterol	1.07	0.54	↓
L4PN	Particle number	1.04	0.56	↓
L4AB	Apo-B	1.04	0.56	↓
H4A1	Apo-A1	1.04	0.53	↓
ITAC	Cytokine	1.03	0.56	↓
IL1RA	Cytokine	1.03	−0.56	↑
MDC	Cytokine	1.03	−0.57	↑
LDCH	Cholesterol	1.02	0.54	↓
R2	0.67
Q2	0.42
CV-ANOVA	0.06

First letter denotes principal lipoprotein fraction: V, very-low-density lipoprotein; L, low-density lipoprotein; ID, intermediate-density lipoprotein; H, high-density lipoprotein.

Subfractions of principal lipoprotein fractions are shown by a number indicating density of that subfraction; the higher the number, the greater the density.

CV-ANOVA, analysis of variance of cross-validated predictive residuals; VIP, variable influence of projection.