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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Diagn Cytopathol. 2022 Aug 8;50(11):518–524. doi: 10.1002/dc.25030

Table 3:

HPV testing and histologic outcomes of Pap tests from transmasculine individuals receiving testosterone from this cohort and the literature

Study Current study Adkins et al (2018) Williams et al (2020) Plummer et al (2021)

Cytology Histology Cytology Histology Cytology* Cytology Histology

HPV-positive cases 2 NILM 1 benign/1 no FU 1 NILM 1 benign 1 NILM 4 NILM 1 benign/3 no FU
2 ASC-US 2 HSIL 1 ASC-US/1 ASC-H 1 no FU/1 LSIL 1 ASCUS 1 LSIL
2 HSIL 2 HSIL 1 HSIL 1 HSIL

HPV-negative cases 22 NILM 12 benign/10 no FU 6 NILM 6 benign 3 NILM 16 NILM 6 benign/10 no FU
1 ASC-US 1 benign 2 ASC-US 2 benign 1 ASC-US 2 ASC-US/1 AGC 2 benign/1 LSIL
3 UNSAT 1 benign/2 no FU 4 UNSAT 4 benign

HPV-positive rate 6/32 (19%) 4/12 (33%) 1/5 (20%) 5/27 (18.5%)
*

no histologic outcome available according to HPV testing;

NILM: negative for intraepithelial lesion or malignancy; FU: follow-up; ASCUS: atypical squamous cells of undetermined significance; HSIL: high-grade squamous intraepithelial lesion; LSIL: low-grade squamous intraepithelial lesion; ASC-H: atypical squamous cells of undetermined significance, cannot rule out HSIL; AGC: atypical glandular cells; UNSAT: unsatisfactory